Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular quantum thermometry
arXiv:2006.11746 · doi:10.1038/s41598-021-83285-y
Abstract
In this study, we analyze the operational process of nanodiamond (ND) quantum thermometry based on wide-field detection of optically detected magnetic resonance (ODMR) of nitrogen vacancy centers, and compare its performance with that of confocal ODMR detection. We found that (1) the thermometry results are significantly affected by the shape and size of the camera region of interest (ROI) surrounding the target NDs and that (2) by properly managing the ROI and acquisition parameters of the camera, a temperature precision comparable to confocal detection in living cells can be obtained by wide-field ODMR. Our results are significant to the development of camera-based real-time large-area quantum thermometry of living cells.
13 pages, 10 figures
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Cited by in corpus (7)
- Diamond quantum thermometry: From foundations to applications
- Optimal control of a nitrogen-vacancy spin ensemble in diamond for sensing in the pulsed domain
- Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
- Quantum-grade nanodiamonds for ultrabright spin detection in live cells
- Spatially resolved lock-in micro-thermography (SR-LIT): A tensor analysis-enhanced method for anisotropic thermal characterization
- Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing
- Widefield quantum microscopy with nitrogen-vacancy centers in diamond: strengths, limitations, and prospects