Micron-scale SABRE-enhanced NV-NMR Spectroscopy

Abstract

Optically-probed nitrogen-vacancy (NV) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 picoliters. However, a key challenge for NV-NMR is detecting samples at millimolar concentrations. Here, we demonstrate an improvement in NV-NMR proton concentration sensitivity of about $10^5$ over thermal polarization by hyperpolarizing sample proton spins through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR of small molecule sample concentrations as low as 1 millimolar in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low concentration molecules and their dynamics in complex micron-scale systems such as single-cells.

arXiv comment5 pages, 4 figures

References in corpus (5)

• High-sensitivity diamond magnetometer with nanoscale resolution
• Sensitivity Optimization for NV-Diamond Magnetometry
• High Resolution Magnetic Resonance Spectroscopy Using Solid-State Spins
• Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor
• Quantum diamond spectrometer for nanoscale NMR and ESR spectroscopy

Cited by in corpus (21)

• Single-molecule Scale Magnetic Resonance Spectroscopy using Nitrogen-Vacancy Centers in Diamond
• Diamond surface engineering for molecular sensing with nitrogen-vacancy centers
• Exploiting ionization dynamics in the nitrogen vacancy center for rapid, high-contrast spin and charge state initialization
• High-precision mapping of diamond crystal strain using quantum interferometry
• Hyperpolarisation of external nuclear spins using nitrogen-vacancy centre ensembles
• High-Resolution NMR Spectroscopy at Large Fields with Nitrogen Vacancy Centers
• Roadmap on Nanoscale Magnetic Resonance Imaging
• An integrated magnetometry platform with stackable waveguide-assisted detection channels for sensing arrays
• Geometry dependence of micron-scale NMR signals on NV-diamond chips
• Dynamical decoupling methods in nanoscale NMR
• Detection of Molecular Transitions with Nitrogen-Vacancy Centers and Electron-Spin Labels
• Enhancing polarization transfer from nitrogen-vacancy centers in diamond to external nuclear spins via dangling bond mediators
• Robust microwave cavity control for NV ensemble manipulation
• Pulse sequence design for high field NMR with NV centers in dipolarly coupled samples
• Tailored Ion Beam for Precise Color Center Creation
• Efficient Detection of Statistical RF Fields at High Magnetic Field with a Quantum Sensor
• Enhanced sensitivity in microscale high-field NMR via nuclear-spin locking with NV centers
• Enhanced microscale NMR spectroscopy of low-gyromagnetic ratio nuclei via hydrogen transfer
• Quantum Memory Enhanced Multipoint Correlation Spectroscopy for Statistically Polarized NMR
• Amplified Nanoscale Detection of Labelled Molecules via Surface Electrons on Diamond
• Hierarchical Maximum Likelihood Estimation for Time-Resolved NMR Data