Single DNA Electron Spin Resonance Spectroscopy in Aqueous Solutions
arXiv:2002.08425 · doi:10.1038/s41592-018-0084-1
Abstract
Magnetic resonance spectroscopy of single biomolecules under near-physiological conditions may substantially advance understanding of biological function, yet remains very challenging. Here we use nitrogen-vacancy centers in diamonds to detect electron spin resonance spectra of individual, tethered DNA duplexes labeled with a nitroxide spin label in aqueous buffer solutions at ambient temperatures. This paves the way for magnetic resonance studies on single biomolecules and their inter-molecular interactions in a native-like environment.
22 pages, 14 figures
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Cited by in corpus (21)
- Single-molecule Scale Magnetic Resonance Spectroscopy using Nitrogen-Vacancy Centers in Diamond
- Nanoscale Dynamic Readout of a Chemical Redox Process Using Radicals Coupled with Nitrogen-Vacancy Centers in Nanodiamonds
- Diamond surface engineering for molecular sensing with nitrogen-vacancy centers
- Single electron-spin-resonance detection by microwave photon counting
- Biocompatible surface functionalization architecture for a diamond quantum sensor
- High-fidelity single-shot readout of single electron spin in diamond with spin-to-charge conversion
- Quantum sensing of paramagnetic spins in liquids with spin qubits in hexagonal boron nitride
- Experimental observation of dynamical bulk-surface correspondence for topological phases
- Electron-electron double resonance detected NMR spectroscopy using ensemble NV centers at 230 GHz and 8.3 Tesla
- In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors
- Demonstration of NV-detected ESR spectroscopy at 115 GHz and 4.2 Tesla
- Preparation of Metrological States in Dipolar-Interacting Spin Systems
- Long-range interacting Stark many-body probes with Super-Heisenberg precision
- Enhancement of quantum coherence in solid-state qubits via interface engineering
- Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field
- Noise prediction and reduction of single electron spin by deep-learning-enhanced feedforward control
- Nanoscale spin detection of copper ions using double electron-electron resonance at room temperature
- Quantum relaxometry for detecting biomolecular interactions with single NV centers
- Parallel accelerated electron paramagnetic resonance spectroscopy using diamond sensors
- Engineering diamond interfaces free of dark spins
- Parallel optically detected magnetic resonance spectrometer for dozens of single nitrogen-vacancy centers using laser-spot lattice