Tailored nanodiamonds for hyperpolarized 13C MRI

Abstract

Nanodiamond is poised to become an attractive material for hyperpolarized 13C MRI if large nuclear polarizations can be achieved without the accompanying rapid spin-relaxation driven by paramagnetic species. Here we report enhanced and long-lived 13C polarization in synthetic nanodiamonds tailored by acid-cleaning and air-oxidation protocols. Our results separate the contributions of different paramagnetic species on the polarization behavior, identifying the importance of substitutional nitrogen defect centers in the nanodiamond core. These results are likely of use in the development of nanodiamond-based imaging agents with size distributions of relevance for examining biological processes.

References in corpus (10)

• The nitrogen-vacancy colour centre in diamond
• Observing bulk diamond spin coherence in high-purity nanodiamonds
• In-vivo magnetic resonance imaging of hyperpolarized silicon particles
• Orientation independent room-temperature optical 13C hyperpolarization in powdered diamond
• Dynamic Nuclear Polarization in Silicon Microparticles
• Hyperpolarized Nanodiamond with Long Spin Relaxation Times
• Synthesis of Long-T1 Silicon Nanoparticles for Hyperpolarized 29Si Magnetic Resonance Imaging
• Radical-free dynamic nuclear polarization using electronic defects in silicon
• Effect of surface oxidation on electron spin coherence of single nitrogen-vacancy centers in nanodiamonds
• Decay of nuclear hyperpolarization in silicon microparticles

Cited by in corpus (5)

• Efficient Conversion of Nitrogen to Nitrogen-Vacancy Centers in Diamond Particles with High-Temperature Electron Irradiation
• Metal Ions based Dynamic Nuclear Polarization: MI-DNP
• ${}^{13}$C Hyperpolarization with Nitrogen-Vacancy Centers in Micro- and Nanodiamonds for Sensitive Magnetic Resonance Applications
• Controlled synthesis and characterization of porous silicon nanoparticles for dynamic nuclear polarization
• Robust external spin hyperpolarization of quadrupolar nuclei enabled by strain