Inter-residue, inter-protein and inter-family coevolution: bridging the scales

Abstract

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. While being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

12 pages, review paper

References in corpus (2)

• Identification of direct residue contacts in protein-protein interaction by message passing
• Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model

Cited by in corpus (4)

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