1.1k citations · 1.5k across the 5 of their papers we have counts for
5 papers
Inter-residue, inter-protein and inter-family coevolution: bridging the scales
Hendrik Szurmant, Martin Weigt
Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of eno…
Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by Direct Coupling Analysis
Guido Uguzzoni, Shalini John Lovis, Francesco Oteri +3
Proteins have evolved to perform diverse cellular functions, from serving as reaction catalysts to coordinating cellular propagation and development. Frequently, proteins do not ex…
Inter-protein sequence co-evolution predicts known physical interactions in bacterial ribosomes and the trp operon
Christoph Feinauer, Hendrik Szurmant, Martin Weigt +1
Interaction between proteins is a fundamental mechanism that underlies virtually all biological processes. Many important interactions are conserved across a large variety of speci…
Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks
Andrea Procaccini, Bryan Lunt, Hendrik Szurmant +2
Predictive understanding of the myriads of signal transduction pathways in a cell is an outstanding challenge of systems biology. Such pathways are primarily mediated by specific b…
Identification of direct residue contacts in protein-protein interaction by message passing
M. Weigt, R. A. White, H. Szurmant +2
Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein database…