Glassy dynamics of a model of bacterial cytoplasm with metabolic activities

Abstract

Recent experiments have revealed that cytoplasms become glassy when their metabolism is suppressed, while they maintain fluidity in a living state. The mechanism of this active fluidization is not clear, especially for bacterial cytoplasms, since they lack traditional motor proteins, which can cause directed motions. We introduce a model of bacterial cytoplasm focusing on the impact of conformational change in proteins due to metabolism. In the model, proteins are treated as particles under thermal agitation, and conformation changes are treated as changes in particle volume. Simulations revealed that a small change in volume fluidizes the glassy state, accompanied by a change in fragility, as observed experimentally.

arXiv comment6 pages, 4 figures

References in corpus (30)

• Collective motion
• Theoretical perspective on the glass transition and amorphous materials
• Motility-Induced Phase Separation
• A density-independent glass transition in biological tissues
• Amorphous Systems in Athermal, Quasistatic Shear
• Collective Motion of Vibrated Polar Disks
• Dynamics of Highly Supercooled Liquids:Heterogeneity, Rheology, and Diffusion
• Emergent behavior in active colloids
• Fluid Flows Created by Swimming Bacteria Drive Self-Organization in Confined Suspensions
• Active Jamming: Self-propelled soft particles at high density
• Swarming and swirling in self-propelled polar granular rods
• Nonequilibrium glass transitions in driven and active matter
• Pushing the glass transition towards random close packing using self-propelled hard spheres
• Nonequilibrium glassy dynamics of self-propelled hard disks
• Glassy dynamics of athermal self-propelled particles: Computer simulations and a nonequilibrium microscopic theory
• Compressing nearly hard sphere fluids increases glass fragility
• The nonequilibrium glassy dynamics of self-propelled particles
• Hydrodynamic Collective Effects of Active Protein Machines in Solution and Lipid Bilayers
• Exothermicity is not a necessary condition for enhanced diffusion of enzymes
• Activity controls fragility: A Random First Order Transition Theory for an active glass
• How active forces influence nonequilibrium glass transitions
• Active fluidization in dense glassy systems
• Mode-Coupling Theory for Active Brownian Particles
• From single-particle to collective effective temperatures in an active fluid of self-propelled particles
• Nonequilibrium mode-coupling theory for dense active systems of self-propelled particles
• Universal, additive effect of temperature on the rheology of amorphous solids
• Purely hydrodynamic origin for swarming of swimming particles
• Discontinuous fluidisation transition in assemblies of actively-deforming particles: A new paradigm for collective motion in dense active materials
• Glassy swirls of active dumbbells
• Do hydrodynamically assisted binary collisions lead to orientational ordering of microswimmers?

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• Instantaneous Normal Modes Reveal Structural Signatures for the Herschel-Bulkley Rheology in Sheared Glasses
• Biased ensembles of pulsating active matter
• A near-term quantum simulation of the transverse field Ising model hints at Glassy Dynamics
• Diffusive oscillators capture the pulsating states of deformable particles
• Mobility-induced kinetic effects in multicomponent mixtures
• Structural fluctuations in active glasses