Biopolymers: life's mechanical scaffolds

Abstract

The cells and tissues that make up our body juggle contradictory mechanical demands. It is crucial for their survival to be able to withstand large mechanical loads, but it is equally crucial for them to produce forces and actively change shape during biological processes such as tissue growth and repair. The mechanics of cell and tissues is determined by scaffolds of protein polymers known as the cytoskeleton and the extracellular matrix, respectively. Experiments on model systems reconstituted from purified components combined with polymer physics concepts have already successfully uncovered some of the mechanisms that underlie the paradoxical mechanics of living matter. Initial work focussed on explaining universal features such as the nonlinear elasticity of cells and tissues in terms of polymer network models. However, living matter exhibits many advanced mechanical functionalities that are not captured by these coarse-grained theories. In this Review, we focus on recent experimental and theoretical insights revealing how their porous structure, structural hierarchy, transient crosslinking, and mechanochemical activity confer resilience combined with the ability to adapt and self-heal. These physical insights improve our understanding of cell and tissue biology and also provide a source of inspiration for synthetic life-like materials.

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Cited by in corpus (16)

• Active polymer rings: activity-induced collapse and dynamical arrest
• A review of active matter reviews
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• Modeling mechanochemical pattern formation in elastic sheets of biological matter
• Power Law Rheology of Folded Protein Hydrogels
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• Network Model of Active Fluctuations of Thin Elastic Shells Swollen by Hydrostatic Pressure
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• TopoGEN: topology-driven microstructure generation for in silico modeling of fiber network mechanics
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• Cross-linked pair of polymer chains under strong tension