Role of turn-over in active stress generation in a filament network

Abstract

We study the effect of turnover of cross linkers, motors and filaments on the generation of a contractile stress in a network of filaments connected by passive crosslinkers and subjected to the forces exerted by molecular motors. We perform numerical simulations where filaments are treated as rigid rods and molecular motors move fast compared to the timescale of exchange of crosslinkers. We show that molecular motors create a contractile stress above a critical number of crosslinkers. When passive crosslinkers are allowed to turn over, the stress exerted by the network vanishes, due to the formation of clusters. When both filaments and passive crosslinkers turn over, clustering is prevented and the network reaches a dynamic contractile steady-state. A maximum stress is reached for an optimum ratio of the filament and crosslinker turnover rates.

17 pages, 8 figures, 5 supplementary movies (included in the source) In the latest version, appendices D and E have been added, text has been updated, Figure 2 has been corrected, and Figure 4 has been replaced by simulation results with higher precision

References in corpus (2)

• Mechanical response of active gels
• Geometrical origins of contractility in disordered actomyosin networks

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