Fiber networks amplify active stress

Abstract

Large-scale force generation is essential for biological functions such as cell motility, embryonic development, and muscle contraction. In these processes, forces generated at the molecular level by motor proteins are transmitted by disordered fiber networks, resulting in large-scale active stresses. While these fiber networks are well characterized macroscopically, this stress generation by microscopic active units is not well understood. Here we theoretically study force transmission in these networks, and find that local active forces are rectified towards isotropic contraction and strongly amplified as fibers collectively buckle in the vicinity of the active units. This stress amplification is reinforced by the networks' disordered nature, but saturates for high densities of active units. Our predictions are quantitatively consistent with experiments on reconstituted tissues and actomyosin networks, and shed light on the role of the network microstructure in shaping active stresses in cells and tissue.

8 pages, 4 figures. Supporting information: 5 pages, 5 figures

References in corpus (9)

• Mayavi: a package for 3D visualization of scientific data
• Programmable Mechanical Metamaterials
• Nonaffine rubber elasticity for stiff polymer networks
• Microbuckling of Fibrin Provides a Mechanism for Cell Mechanosensing
• Crosslinked networks of stiff filaments exhibit negative normal stress
• A Model for Compression-Weakening Materials and the Elastic Fields due to Contractile Cells
• Actively stressed marginal networks
• Scaling laws for the response of nonlinear elastic media with implications for cell mechanics
• Force distributions and force chains in random stiff fiber networks

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• Many-body interactions between contracting living cells
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• Programming Boundary Deformation Patterns in Active Networks
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• Collective dynamics and self-organization of active particles on random networks
• Nonlinear master relation in microscopic mechanical response of semiflexible biopolymer networks