Simulation of morphogen and tissue dynamics

Abstract

Morphogenesis, the process by which an adult organism emerges from a single cell, has fascinated humans for a long time. Modelling this process can provide novel insights into development and the principles that orchestrate the developmental processes. This chapter focusses on the mathematical description and numerical simulation of developmental processes. In particular, we discuss the mathematical representation of morphogen and tissue dynamics on static and grow- ing domains, as well as the corresponding tissue mechanics. In addition, we give an overview of numerical methods that are routinely used to solve the resulting systems of partial differential equations. These include the finite element method and the Lattice Boltzmann method for the discretisation as well as the arbitrary Lagrangian-Eulerian method and the Diffuse-Domain method to numerically treat deforming domains.

References in corpus (5)

• LBIBCell: A Cell-Based Simulation Environment for Morphogenetic Problems
• Adhesion between cells, diffusion of growth factors, and elasticity of the AER produce the paddle shape of the chick limb
• Simulation Organogenesis in COMSOL: Deforming and Interacting Domains
• Simulating Organogenesis in COMSOL: Image-based Modeling
• Simulating Organogenesis in COMSOL: Comparison Of Methods For Simulating Branching Morphogenesis