Three-dimensional alteration of neurites in schizophrenia

Abstract

This paper reports nano-CT analysis of brain tissues of schizophrenia and control cases. The analysis revealed that: (1) neuronal structures vary between individuals, (2) the mean curvature of distal neurites of the schizophrenia cases was 1.5 times higher than that of the controls, and (3) dendritic spines were categorized into two geometrically distinctive groups, though no structural differences were observed between the disease and control cases. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.

arXiv comment24 pages, 4 figures, and 1 table. Supplementary materials are available from DOI link

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Cited by in corpus (5)

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• Structural diverseness of neurons between brain areas and between cases