Kinetic Selection of Template Polymer with Complex Sequences
arXiv:1803.10999 · doi:10.1103/PhysRevLett.121.118101
Abstract
Emergence and maintenance of polymers with complex sequences is a major question in the study of origins of life. To answer this, we studied a model polymerization reaction, where polymers are synthesized by stepwise ligation from two types of monomers, catalyzed by a long polymer as a template. Direct stochastic simulation and dynamical systems analysis revealed that the most dominant polymer sequence in a population successively changes against the flow rate of monomer to the system. The slower the flow, the more is the complex sequence selected. We discuss the relevance of this kinetic selection of sequence by the non-equilibrium flow rate to the origin of complex polymers.
arXiv comment12 pages, 12 figures
References in corpus (7)
- A noise-induced mechanism for biological homochirality of early life self-replicators
- A generic mechanism for adaptive growth rate regulation
- Emergence of information transmission in a prebiotic RNA reactor
- The origin of large molecules in primordial autocatalytic reaction networks
- Optimal size for emergence of self-replicating polymer system
- Sequence selection in an autocatalytic binary polymer model
- Inverse Relationship Between Molecular Diversity And Resource Abundances