Multivalent cation induced attraction of anionic polymers by like-charged pores
arXiv:1707.00562 · doi:10.1063/1.4994018
Abstract
The efficiency of nanopore-based polymer sensing devices depends on the fast capture of anionic polyelectrolytes by negatively charged pores. This requires the cancellation of the electrostatic barrier associated with repulsive polymer-pore interactions. We develop a correlation-corrected theory to show that the barrier experienced by the polymer can be efficiently overcome by the addition of multivalent cations into the electrolyte solution. Cation adsorption into the pore enhances the screening ability of the pore medium with respect to the bulk reservoir which translates into an attractive force on the polymer. Beyond a critical multivalent cation concentration, this correlation-induced attraction overcomes the electrostatic barrier and triggers the adsorption of the polymer by the like-charged pore. It is shown that like-charge polymer-pore attraction is suppressed by monovalent salt but enhanced by the membrane charge strength and the pore confinement. Our predictions may provide enhanced control over polymer motion in translocation experiments.
References in corpus (18)
- Polymer Translocation througha Pore in a Membrane
- Collapse of Flexible Polyelectrolytes in Multivalent Salt Solutions
- Unifying model of driven polymer translocation
- Simple Model for Attraction between Like-Charged Polyions
- Collapse of Stiff Polyelectrolytes due to Counterion Fluctuations
- Translocation frequency of double-stranded DNA through a solid-state nanopore
- Flexible Linear Polyelectrolytes in Multivalent Salt Solutions: Solubility Conditions
- DNA translocation through nanopores with salt gradients: The role of osmotic flow
- Effective charge and free energy of DNA inside an ion channel
- Electrophoresis of a polyelectrolyte through a nanopore
- Self-energy limited ion transport in sub-nanometer channels
- Charge neutrality breakdown in confined aqueous electrolytes: theory and simulation
- Polymer translocation under time-dependent driving forces: resonant activation induced by attractive polymer-pore interactions
- Electrophoretic Capture of a DNA Chain into a Nanopore
- Electrostatic correlations on the ionic selectivity of cylindrical membrane nanopores
- Like-charge attraction and opposite-charge decomplexation between polymers and DNA molecules
- Correlation-induced DNA adsorption on like-charged membranes
- Controlling Polymer Capture and Translocation by Electrostatic Polymer-Pore Interactions
Cited by in corpus (3)
- Enhanced polymer capture speed and extended translocation time in pressure-solvation traps
- Modified Poisson-Boltzmann theory for polyelectrolytes in monovalent salt solutions with finite-size ions
- Interactions between polyelectrolytes mediated by ordering and orientation of multivalent non-spherical ions in salt solutions