Electrophoresis of a polyelectrolyte through a nanopore

Abstract

A hydrodynamic model for determining the electrophoretic speed of a polyelectrolyte through a nanopore is presented. It is assumed that the speed is determined by a balance of electrical and viscous forces arising from within the pore and that classical continuum electrostatics and hydrodynamics may be considered applicable. An explicit formula for the translocation speed as a function of the pore geometry and other physical parameters is obtained and is shown to be consistent with experimental measurements on DNA translocation through nanopores in silicon membranes. Experiments also show a weak dependence of the translocation speed on polymer length that is not accounted for by the present model. It is hypothesized that this is due to secondary effects that are neglected here.

5 pages, 2 column, 2 figures

References in corpus (2)

• Fast DNA translocation through a solid-state nanopore
• DNA in nanopore-counterion condensation and coion depletion

Cited by in corpus (16)

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• Adaptive and Iterative Methods for Simulations of Nanopores with the PNP-Stokes Equations
• Ionic current inversion in pressure-driven polymer translocation through nanopores
• Controlling Polymer Capture and Translocation by Electrostatic Polymer-Pore Interactions
• Multivalent cation induced attraction of anionic polymers by like-charged pores
• Enhanced polymer capture speed and extended translocation time in pressure-solvation traps
• Dielectric manipulation of polymer translocation dynamics in engineered membrane nanopores
• Electrostatics of polymer translocation events in electrolyte solutions
• Steric modulation of ionic currents in DNA translocation through nanopores