Impact of a non-uniform charge distribution on virus assembly
arXiv:1705.02539 · doi:10.1103/PhysRevE.96.022401
Abstract
Many spherical viruses encapsulate their genome in protein shells with icosahedral symmetry. This process is spontaneous and driven by electrostatic interactions between positive domains on the virus coat proteins and the negative genome. We model the effect of the icosahedral charge distribution from the protein shell instead of uniform using a mean-field theory. We find that the non-uniform charge distribution strongly affects the optimal genome length, and that it can explain the experimentally observed phenomenon of overcharging of virus and virus-like particles.
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- Landau theory and self-assembly of spherical nanoclusters and nanoparticles with octahedral symmetry
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- Symmetry breaking of dipole orientations on Caspar-Klug lattices
- Charge mechanism of low-frequency stimulated Raman scattering in virus suspensions