How simple can a model of an empty viral capsid be? Charge distributions in viral capsids

Abstract

We investigate and quantify salient features of the charge distributions on viral capsids. Our analysis combines the experimentally determined capsid geometry with simple models for ionization of amino acids, thus yielding the detailed description of spatial distribution for positive and negative charge across the capsid wall. The obtained data is processed in order to extract the mean radii of distributions, surface charge densities and dipole moment densities. The results are evaluated and examined in light of previously proposed models of capsid charge distributions, which are shown to have to some extent limited value when applied to real viruses.

10 pages, 10 figures; accepted for publication in Journal of Biological Physics

References in corpus (2)

• Role of electrostatic interactions in the assembly of empty spherical viral capsids
• Electrostatic self-energy of a partially formed spherical shell in salt solution: application to stability of tethered and fluid shells -- viruses and vesicles

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