Mapping the Microscale Origins of MRI Contrast with Subcellular NV Diamond Magnetometry
arXiv:1610.01924 · doi:10.1038/s41467-017-02471-7
Abstract
Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field gradients in biological tissues. However, the connection between these sub-voxel field patterns and MRI contrast has not been studied experimentally. Here, we describe a new method to map subcellular magnetic fields in mammalian cells and tissues using nitrogen vacancy diamond magnetometry and connect these maps to voxel-scale MRI contrast, providing insights for in vivo imaging and contrast agent design.
References in corpus (6)
- Nanometer scale quantum thermometry in a living cell
- Optical magnetic detection of single-neuron action potentials using quantum defects in diamond
- Magnetic spin imaging under ambient conditions with sub-cellular resolution
- Self-aligned nanoscale SQUID on a tip
- Proton magnetic resonance imaging with a nitrogen-vacancy spin sensor
- Nanoscale magnetometry through quantum control of nitrogen-vacancy centres in rotationally diffusing nanodiamonds
Cited by in corpus (24)
- Sensitivity Optimization for NV-Diamond Magnetometry
- Simultaneous Broadband Vector Magnetometry Using Solid-State Spins
- Imaging crystal stress in diamond using ensembles of nitrogen-vacancy centers
- Diamond magnetic microscopy of malarial hemozoin nanocrystals
- Detection of biological signals from a live mammalian muscle using a diamond quantum sensor
- Is a quantum biosensing revolution approaching?
- Fiber-coupled Diamond Magnetometry with an Unshielded 30 pT/ Sensitivity
- Optimisation of a diamond nitrogen vacancy centre magnetometer for sensing of biological signals
- Broadband loop gap resonator for nitrogen vacancy centers in diamond
- Microwave-assisted spectroscopy technique for studying charge state in nitrogen-vacancy ensembles in diamond
- Enhancing Optical Readout from Diamond AFM Tips for Quantum Nanosensing
- Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
- Ferrimagnetic Oscillator Magnetometer
- Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing
- Tensor gradiometry with a diamond magnetometer
- Diamond Nitrogen-Vacancy Center Magnetometry: Advances and Challenges
- Time-resolved diamond magnetic microscopy of superparamagnetic iron-oxide nanoparticles
- Diamond quantum sensors in microfluidics technology
- High-resolution spectroscopy of a single nitrogen-vacancy defect at zero magnetic field
- Endoscopic fiber-coupled diamond magnetometer for cancer surgery
- A Fully-integrated Diamond Nitrogen-Vacancy Magnetometer with Nanotesla Sensitivity
- Widefield quantum microscopy with nitrogen-vacancy centers in diamond: strengths, limitations, and prospects
- Diamond-based optical vector magnetometer
- Photoconversion of shallow nitrogen-vacancy centers in flat and nanostructured diamond under high-power laser irradiation