Collective chemotaxis through noisy multicellular gradient sensing

Abstract

Collective cell migration in response to a chemical cue occurs in many biological processes such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems are capable of responding to gradients of less than 1% difference in chemical concentration across a cell length. Multicellular systems are extremely sensitive to their environment and while the limits to multicellular sensing are becoming known, how this information leads to coherent migration remains poorly understood. We develop a computational model of multicellular sensing and migration in which groups of cells collectively measure noisy chemical gradients. The output of the sensing process is coupled to individual cells polarization to model migratory behavior. Through the use of numerical simulations, we find that larger clusters of cells detect the gradient direction with higher precision and thus achieve stronger polarization bias, but larger clusters also induce more drag on collective motion. The trade-off between these two effects leads to an optimal cluster size for most efficient migration. We discuss how our model could be validated using simple, phenomenological experiments.

11 pages, 4 figures, 1 table

References in corpus (4)

• Novel type of phase transition in a system of self-driven particles
• Collective signal processing in cluster chemotaxis: roles of adaptation, amplification, and co-attraction in collective guidance
• Molecular-level tuning of cellular autonomy controls the collective behaviors of cell populations
• Sense and sensitivity: physical limits to multicellular sensing, migration and drug response

Cited by in corpus (7)

• Physical constraints on accuracy and persistence during breast cancer cell chemotaxis
• Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing
• Emergent versus Individual-based Multicellular Chemotaxis
• Tumor Spheroid Chemotaxis in Epidermal Growth Factor Gradients Revealed by a 3D Microfluidic Device
• Effects of cell-cell adhesion on migration of multicellular clusters
• Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients
• Theoretical constraints imposed by gradient detection and dispersal on microbial size in astrobiological environments