Correlations and Symmetry of Interactions Influence Collective Dynamics of Molecular Motors

Abstract

Enzymatic molecules that actively support many cellular processes, including transport, cell division and cell motility, are known as motor proteins or molecular motors. Experimental studies indicate that they interact with each other and they frequently work together in large groups. To understand the mechanisms of collective behavior of motor proteins we study the effect of interactions in the transport of molecular motors along linear filaments. It is done by analyzing a recently introduced class of totally asymmetric exclusion processes that takes into account the intermolecular interactions via thermodynamically consistent approach. We develop a new theoretical method that allows us to compute analytically all dynamic properties of the system. Our analysis shows that correlations play important role in dynamics of interacting molecular motors. Surprisingly, we find that the correlations for repulsive interactions are weaker and more short-range than the correlations for the attractive interactions. In addition, it is shown that symmetry of interactions affect dynamic properties of molecular motors. The implications of these findings for motor proteins transport are discussed. Our theoretical predictions are tested by extensive Monte Carlo computer simulations.

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Cited by in corpus (11)

• Crowding and pausing strongly affect dynamics of kinesin-1 motors along microtubules
• Collective dynamics on a two-lane asymmetrically coupled TASEP with mutually interactive Langmuir Kinetics
• Role of interactions and correlations on collective dynamics of molecular motors along parallel filaments
• A Deterministic Model for One-Dimensional Excluded Flow with Local Interactions
• One-dimensional irreversible aggregation with TASEP dynamics
• Dynamics of relaxation to a stationary state for interacting molecular motors
• Role of interactions in a closed quenched system
• Dynamical transitions in a driven diffusive model with interactions
• A Multispecies Exclusion Process with Fusion and Fission of Rods: a model inspired by Intraflagellar Transport
• Exclusion process on an open lattice with fluctuating boundaries
• Steady-state dynamics of exclusion process with local reversible association of particles