Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors

Abstract

Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials. We investigate the fundamental role of these interactions by analyzing a new class of totally asymmetric exclusion processes where interactions are accounted for in a thermodynamically consistent fashion. Theoretical analysis that combines various mean-field cal- culations and computer simulations suggests that dynamic properties of molecular motors strongly depend on interactions, and correlations are stronger for interacting motor proteins. Surprisingly, it is found that there is an optimal strength of interactions (weak repulsion) that leads to a maxi- mal particle flux. It is also argued that molecular motors transport is more sensitive to attractive interactions. Applications of these results for kinesin motor proteins are discussed.

References in corpus (6)

• Phase Coexistence in Driven One Dimensional Transport
• Traffic of molecular motors through tube-like compartments
• Phase transitions in systems with two species of molecular motors
• Weakly coupled, antiparallel, totally asymmetric simple exclusion processes
• Entrainment and unit velocity: Surprises in an accelerated exclusion process
• Interaction of molecular motors can enhance their efficiency

Cited by in corpus (16)

• Correlations and Symmetry of Interactions Influence Collective Dynamics of Molecular Motors
• Crowding and pausing strongly affect dynamics of kinesin-1 motors along microtubules
• Collective dynamics on a two-lane asymmetrically coupled TASEP with mutually interactive Langmuir Kinetics
• Driven diffusive systems with mutually interactive Langmuir kinetics
• Collective transport of weakly interacting molecular motors with Langmuir kinetics
• Role of interactions and correlations on collective dynamics of molecular motors along parallel filaments
• A Deterministic Model for One-Dimensional Excluded Flow with Local Interactions
• One-dimensional irreversible aggregation with TASEP dynamics
• Dynamics of relaxation to a stationary state for interacting molecular motors
• Effect of self-deflection on a totally asymmetric simple exclusion process with functions of site-assignments
• Role of interactions in a closed quenched system
• A Multispecies Exclusion Process with Fusion and Fission of Rods: a model inspired by Intraflagellar Transport
• Dynamical transitions in a driven diffusive model with interactions
• Throughput reduction on an air-ground transport system by the simultaneous effect of multiple traveling routes equipped with parking sites
• Exclusion process on an open lattice with fluctuating boundaries
• Steady-state dynamics of exclusion process with local reversible association of particles