Ionic current inversion in pressure-driven polymer translocation through nanopores

Abstract

We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.

This version is accepted for publication in Physical Review Letters

References in corpus (10)

• Polymer Translocation througha Pore in a Membrane
• Hydrodynamics within the Electric Double Layer on slipping surfaces
• Effect of Salt Concentration on the Electrophoretic Speed of a Polyelectrolyte through a Nanopore
• Unifying model of driven polymer translocation
• Electrophoresis of a polyelectrolyte through a nanopore
• Self-energy limited ion transport in sub-nanometer channels
• Scaling theory of driven polymer translocation
• Polymer translocation under time-dependent driving forces: resonant activation induced by attractive polymer-pore interactions
• Chain deformation helps translocation
• Electrostatic correlations on the ionic selectivity of cylindrical membrane nanopores

Cited by in corpus (10)

• On the nature of overcharging and charge inversion in electrical double layers
• Wetting of nanopores probed with pressure
• Beyond Poisson-Boltzmann: fluctuations and fluid structure in a self-consistent theory
• Enhanced polymer capture speed and extended translocation time in pressure-solvation traps
• Nanofluidic charge transport under strong electrostatic coupling conditions
• Ion-mediated interactions between net-neutral slabs: Weak and strong disorder effects
• Dielectric anisotropy in polar solvents under external fields
• Electrostatic energy barriers from dielectric membranes upon approach of translocating DNA molecules
• Electrostatic interactions in charged nanoslits within an explicit solvent theory
• Dielectric trapping of biopolymers translocating through insulating membranes