Resolving single molecule structures with nitrogen-vacancy centers in diamond

Abstract

We present theoretical proposals for two-dimensional nuclear magnetic resonance spectroscopy protocols based on Nitrogen-vacancy (NV) centers in diamond that are strongly coupled to the target nuclei. Continuous microwave and radio-frequency driving fields together with magnetic field gradients achieve Hartmann-Hahn resonances between NV spin sensor and selected nuclei for control of nuclear spins and subsequent measurement of their polarization dynamics. The strong coupling between the NV sensor and the nuclei facilitates coherence control of nuclear spins and relaxes the requirement of nuclear spin polarization to achieve strong signals and therefore reduced measurement times. Additionally, we employ a singular value thresholding matrix completion algorithm to further reduce the amount of data required to permit the identification of key features in the spectra of strongly sub-sampled data. We illustrate the potential of this combined approach by applying the protocol to a shallowly implanted NV center addressing a small amino acid, alanine, to target specific hydrogen nuclei and to identify the corresponding peaks in their spectra.

7 pages, 5 figures

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• One- and two-dimensional nuclear magnetic resonance spectroscopy with a diamond quantum sensor
• Towards optimized surface $\delta$-profiles of nitrogen-vacancy centers activated by helium irradiation in diamond
• Positioning Nuclear Spins in Interacting Clusters for Quantum Technologies and Bio-imaging
• Roadmap on Nanoscale Magnetic Resonance Imaging
• Parallel detection and spatial mapping of large nuclear spin clusters
• Environmentally mediated coherent control of a spin qubit in diamond
• Quantum Zeno and Zeno-like effects in nitrogen vacancy centers
• Low-frequency quantum sensing
• Proposal for Quantum Sensing Based on Two-Dimensional Dynamical Decoupling: NMR Correlation Spectroscopy of Single Molecules
• Dissipatively stabilized quantum sensor based on indirect nuclear-nuclear interactions
• Accelerated 2D magnetic resonance spectroscopy of single spins using matrix completion
• Multidimensional spectroscopy of nuclear spin clusters in diamond
• Nanoscale magnets embedded in a microstrip
• Wavelet-resolved coherence beats in the Overhauser field of a thermal nuclear spin ensemble