Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones
arXiv:1309.5778 · doi:10.1088/1367-2630/16/6/063032
Abstract
Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP hydrolysis) leads to a collective phenomenon that is currently unknown. Obtaining force-velocity relations for different models that capture chemical switching, we show, analytically and numerically, that the collective stall force of N filaments is greater than N times the stall force of a single filament. Employing an exactly solvable toy model, we analytically prove the above result for N=2. We, further, numerically show the existence of this collective phenomenon, for N>=2, in realistic models (with random and sequential hydrolysis) that simulate actin and microtubule bundle growth. We make quantitative predictions for the excess forces, and argue that this collective effect is related to the non-equilibrium nature of chemical switching.
New J. Phys., 2014
References in corpus (15)
- Actin Polymerization Kinetics, Cap Structure and Fluctuations
- ATP hydrolysis stimulates large length fluctuations in single actin filaments
- The random release of phosphate controls the dynamic instability of microtubules
- Dynamics of Microtubule Growth and Catastrophe
- Non-equilibrium self-assembly of a filament coupled to ATP/GTP hydrolysis
- Role of ATP-hydrolysis in the dynamics of a single actin filament
- Simple Growth Models of Rigid Multifilament Biopolymers
- Zipping mechanism for force-generation by growing filament bundles
- Stall force of polymerizing microtubules and filament bundles
- Condensation of actin filaments pushing against a barrier
- Cooperative dynamics of microtubule ensembles: Polymerization forces and rescue-induced oscillations
- Polymerization dynamics of double-stranded biopolymers: chemical kinetic approach
- Microtubule catastrophe from protofilament dynamics
- Prolonging assembly through dissociation:A self assembly paradigm in microtubules
- Compressive force generation by a bundle of living biofilaments
Cited by in corpus (8)
- Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments
- Sufficient conditions for the additivity of stall forces generated by multiple filaments or motors
- Actin filaments growing against an elastic membrane: Effect of membrane tension
- Actin filaments growing against a barrier with fluctuating shape
- Solvable model of a many-filament Brownian ratchet
- On the force--velocity relationship of a bundle of rigid living filaments
- A semi-flexible model prediction for the polymerization force exerted by a living F-actin filament on a fixed wall
- Actin filaments pushing against a barrier: Comparison between two force generation mechanisms