Actin filaments growing against a barrier with fluctuating shape
arXiv:1606.07553 · doi:10.1103/PhysRevE.93.062414
Abstract
We study force generation by a set of parallel actin filaments growing against a non-rigid obstacle, in presence of an external load. The filaments polymerize by either moving the whole obstacle, with a large energy cost, or by causing local distortion in its shape which costs much less energy. The non-rigid obstacle also has local thermal fluctuations due to which its shape can change with time and we describe this using fluctuations in the height profile of a one dimensional interface with Kardar-Parisi-Zhang dynamics. We find the shape fluctuations of the barrier strongly affects the force generation mechanism. The qualitative nature of the force-velocity curve is crucially determined by the relative time-scale of filament and barrier dynamics. The height profile of the barrier also shows interesting variation with the external load. Our analytical calculation within mean-field theory shows reasonable agreement with our simulation results.
References in corpus (7)
- Dynamics of membranes driven by actin polymerization
- Zipping mechanism for force-generation by growing filament bundles
- Stall force of polymerizing microtubules and filament bundles
- Condensation of actin filaments pushing against a barrier
- The Force-Velocity Relation for Growing Biopolymers
- Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones
- Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments
Cited by in corpus (5)
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- Interplay between surface and bending energy helps membrane protrusion formation
- Filament flexibility enhances power transduction of F-actin bundles
- Actin filaments pushing against a barrier: Comparison between two force generation mechanisms
- Effect of relative timescale on a system of particles sliding on a fluctuating energy landscape: Exact derivation of product measure condition