Wrapping of ellipsoidal nano-particles by fluid membranes

Abstract

Membrane budding and wrapping of particles, such as viruses and nano-particles, play a key role in intracellular transport and have been studied for a variety of biological and soft matter systems. We study nano-particle wrapping by numerical minimization of bending, surface tension, and adhesion energies. We calculate deformation and adhesion energies as a function of membrane elastic parameters and adhesion strength to obtain wrapping diagrams. We predict unwrapped, partially-wrapped, and completely-wrapped states for prolate and oblate ellipsoids for various aspect ratios and particle sizes. In contrast to spherical particles, where partially-wrapped states exist only for finite surface tensions, partially-wrapped states for ellipsoids occur already for tensionless membranes. In addition, the partially-wrapped states are long-lived, because of an increased energy cost for wrapping of the highly-curved tips. Our results suggest a lower uptake rate of ellipsoidal particles by cells and thereby a higher virulence of tubular viruses compared with icosahedral viruses, as well as co-operative budding of ellipsoidal particles on membranes.

10 pages, 11 figures

References in corpus (6)

• Ellipsoidal particles at fluid interfaces
• Mechanism of membrane tube formation induced by adhesive nanocomponents
• Can a Carbon Nanotube Pierce through a Phospholipid Bilayer?
• Effect of interactions on the cellular uptake of nanoparticles
• Budding and vesiculation induced by conical membrane inclusions
• Critical adsorption controls translocation of polymer chains through lipid bilayers and permeation of solvent

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• Cell-Scale Dynamic Modeling of Membrane Interactions with Arbitrarily Shaped Particles