Time-dependent information transmission in a model regulatory circuit

Abstract

Many biological regulatory systems process signals out of steady state and respond with a physiological delay. A simple model of regulation which respects these features shows how the ability of a delayed output to transmit information is limited: at short times by the timescale of the dynamic input, at long times by that of the dynamic output. We find that topologies of maximally informative networks correspond to commonly occurring biological circuits linked to stress response and that circuits functioning out of steady state may exploit absorbing states to transmit information optimally.

arXiv comment14 pages, 8 figures

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• Thermodynamic bounds on spectral perturbations, with applications to oscillations and relaxation dynamics
• Noise Processing by MicroRNA-Mediated Circuits: the Incoherent Feed-Forward Loop, Revisited
• Trade-offs in delayed information transmission in biochemical networks
• Interplay of synergy and redundancy in diamond motif
• Statistics of optimal information flow in ensembles of regulatory motifs
• Characterizing the non-monotonic behavior of mutual information along biochemical reaction cascades
• Dissipation in non-steady state regulatory circuits
• Detecting concentration changes with cooperative receptors