Template-directed biopolymerization: tape-copying Turing machines
arXiv:1212.6827 · doi:10.1142/S1793048012300083
Abstract
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear polymer as the corresponding template. The machine utilizes input chemical energy to move along the template which also serves as a track for the movements of the machine. In the Alan Turing year 2012, it is worth pointing out that these machines are "tape-copying Turing machines". We review the operational mechanisms of the polymerizer machines and their collective behavior from the perspective of statistical physics, emphasizing their common features in spite of the crucial differences in their biological functions. We also draw attention of the physics community to another class of modular machines that carry out a different type of template-directed polymerization. We hope this review will inspire new kinetic models for these modular machines.
Author-edited final version of a review article published in Biophysical Reviews and Letters [copyright World Scientific Publishing Company]; publisher-edited electronic version available at http://www.worldscientific.com/doi/abs/10.1142/S1793048012300083
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- Thermodynamics of Error Correction
- Template-directed growth of copolymers
- A Biologically Motivated Asymmetric Exclusion Process: interplay of congestion in RNA polymerase traffic and slippage of nascent transcript
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