44 citations · 137 across the 8 of their papers we have counts for
8 papers
Quantitative Connection Between Ensemble Thermodynamics and Single-Molecule Kinetics: A Case Study Using Cryogenic Electron Microscopy and Single-Molecule Fluorescence Resonance Energy Transfer Investigations of the Ribosome
Colin D. Kinz-Thompson, Ajeet K. Sharma, Joachim Frank +2
At equilibrium, thermodynamic and kinetic information can be extracted from biomolecular energy landscapes by many techniques. However, while static, ensemble techniques yield ther…
Distribution of lifetimes of kinetochore-microtubule attachments: interplay of energy landscape, molecular motors and microtubule (de-)polymerization
Ajeet K. Sharma, Blerta Shtylla, Debashish Chowdhury
Before a cell divides into two daughter cells, chromosomes are replicated resulting in two sister chromosomes embracing each other. Each sister chromosome is bound to a separate pr…
First-passage problems in DNA replication: effects of template tension on stepping and exonuclease activities of a DNA polymerase motor
Ajeet K. Sharma, Debashish Chowdhury
A DNA polymerase (DNAP) replicates a template DNA strand. It also exploits the template as the track for its own motor-like mechanical movement. In the polymerase mode it elongates…
Template-directed biopolymerization: tape-copying Turing machines
Ajeet K. Sharma, Debashish Chowdhury
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize su…
Error correction during DNA replication
Ajeet K. Sharma, Debashish Chowdhury
DNA polymerase (DNAP) is a dual-purpose enzyme that plays two opposite roles in two different situations during DNA replication. It plays its normal role as a {\it polymerase} cata…
Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript
Ajeet K. Sharma, Debashish Chowdhury
The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecula…
Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding
Ajeet K. Sharma, Debashish Chowdhury
Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triple…
Quality control by a mobile molecular workshop: quality versus quantity
Ajeet K. Sharma, Debashish Chowdhury
Ribosome is a molecular machine that moves on a mRNA track while, simultaneously, polymerizing a protein using the mRNA also as the corresponding template. We define, and analytica…