Flagellar length control in monoflagellates by motorized transport: growth kinetics and correlations of length fluctuations
arXiv:2010.05739 · doi:10.1016/j.physa.2020.125621
Abstract
How does a cell self-organize so that its appendages attain specific lengths that are convenient for their respective functions? What kind of 'rulers' does a cell use to measure the length of these appendages? How does a cell transport structure building materials between the cell body and distal tips of these appendages so as to regulate their dynamic lengths during various stages of its lifetime? Some of these questions are addressed here in the context of a specific cell appendage called flagellum (also called cilium). A "time of flight" (ToF) mechanism, adapted from the pioneering idea of Galileo, has been used successfully very recently to explain the length control of flagella by a biflagellate green algae. Using the same ToF mechanism, here we develop a stochastic model for the dynamics of flagella in two different types of monoflagellate unicellular organisms. A unique feature of these monoflagellates is that these become transiently multi-flagellated during a short span of their life time. The mean length of the flagella in our model reproduce the trend of their temporal variation observed in experiments. Moreover, for probing the intracellular molecular communication between the dynamic flagella of a given cell, we have computed the correlation in the fluctuations of their lengths during the multiflagellated stage of the cell cycle by Monte Carlo simulation.
arXiv commentAccepted for Publication in "Physica A: Statistical Mechanics and its Applications"
References in corpus (17)
- Statistical Physics of Vehicular Traffic and Some Related Systems
- Non-equilibrium statistical mechanics: From a paradigmatic model to biological transport
- Phase Coexistence in Driven One Dimensional Transport
- Physics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms
- Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments
- Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
- Intra-cellular transport of single-headed molecular motors KIF1A
- Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
- Trafficlike collective movement of ants on trails: absence of jammed phase
- Microtubule Length-Regulation by Molecular Motors
- A model of hyphal tip growth involving microtubule-based transport
- Intra-cellular transport by single-headed kinesin KIF1A: effects of single-motor mechano-chemistry and steric interactions
- Traffic of single-headed motor proteins KIF1A: effects of lane changing
- Modelling bacterial flagellar growth
- Template-directed biopolymerization: tape-copying Turing machines
- Flagellar length control in biflagellate eukaryotes: time-of-flight, shared pool, train traffic and cooperative phenomena
- A Multispecies Exclusion Process with Fusion and Fission of Rods: a model inspired by Intraflagellar Transport