Spatio-temporal spike trains analysis for large scale networks using maximum entropy principle and Monte-Carlo method

Abstract

Understanding the dynamics of neural networks is a major challenge in experimental neuroscience. For that purpose, a modelling of the recorded activity that reproduces the main statistics of the data is required. In a first part, we present a review on recent results dealing with spike train statistics analysis using maximum entropy models (MaxEnt). Most of these studies have been focusing on modelling synchronous spike patterns, leaving aside the temporal dynamics of the neural activity. However, the maximum entropy principle can be generalized to the temporal case, leading to Markovian models where memory effects and time correlations in the dynamics are properly taken into account. In a second part, we present a new method based on Monte-Carlo sampling which is suited for the fitting of large-scale spatio-temporal MaxEnt models. The formalism and the tools presented here will be essential to fit MaxEnt spatio-temporal models to large neural ensembles.

41 pages, 10 figures

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• Modeling the correlated activity of neural populations: A review
• Maximum Entropy Principle Analysis in Network Systems with Short-time Recordings
• Optimal encoding in stochastic latent-variable Models
• Inference of stochastic time series with missing data
• Thermodynamic Formalism in Neuronal Dynamics and Spike Train Statistics
• Dynamical and Coupling Structure of Pulse-Coupled Networks in Maximum Entropy Analysis