Dynamic simulations of multicomponent lipid membranes over long length and time scales
arXiv:1105.4898 · doi:10.1103/PhysRevLett.105.148102
Abstract
We present a stochastic phase-field model for multicomponent lipid bilayers that explicitly accounts for the quasi-two-dimensional hydrodynamic environment unique to a thin fluid membrane immersed in aqueous solution. Dynamics over a wide range of length scales (from nanometers to microns) for durations up to seconds and longer are readily accessed and provide a direct comparison to fluorescence microscopy measurements in ternary lipid/cholesterol mixtures. Simulations of phase separation kinetics agree with experiment and elucidate the importance of hydrodynamics in the coarsening process.
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- Geodesic curvature driven surface microdomain formation
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- Drift-Diffusion Dynamics and Phase Separation in Curved Cell Membranes and Dendritic Spines: Hybrid Discrete-Continuum Methods
- Transient domain formation in membrane-bound organelles undergoing maturation
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