Domain Growth, Budding, and Fission in Phase Separating Self-Assembled Fluid Bilayers

Abstract

A systematic investigation of the phase separation dynamics in self-assembled multi-component bilayer fluid vesicles and open membranes is presented. We use large-scale dissipative particle dynamics to explicitly account for solvent, thereby allowing for numerical investigation of the effects of hydrodynamics and area-to-volume constraints. In the case of asymmetric lipid composition, we observed regimes corresponding to coalescence of flat patches, budding, vesiculation and coalescence of caps. The area-to-volume constraint and hydrodynamics have a strong influence on these regimes and the crossovers between them. In the case of symmetric mixtures, irrespective of the area-to-volume ratio, we observed a growth regime with an exponent of 1/2. The same exponent is also found in the case of open membranes with symmetric composition.

References in corpus (3)

• Dynamics of Domain Growth in Self-Assembled Fluid Vesicles
• How would you integrate the equations of motion in dissipative particle dynamics simulations?
• Scale invariance in coarsening of binary and ternary fluids

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• Lipid-protein interaction induced domains: kinetics and conformational changes in multicomponent vesicles
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• Deformation of Equilibrium Shape of a Vesicle Induced by Injected Flexible Polymers