Hybrid Elastic/Discrete-Particle Approach to Biomembrane Dynamics with Application to the Mobility of Curved Integral Membrane Proteins
arXiv:0905.3852 · doi:10.1103/PhysRevLett.102.138102
Abstract
We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surrounding them. Such proteins exhibit a substantial reduction in diffusion coefficient relative to "flat" proteins; this effect is explained by elementary hydrodynamic considerations.
4 pages, 2 figures
References in corpus (5)
- A Stochastic Immersed Boundary Method for Fluid-Structure Dynamics at Microscopic Length Scales
- Lateral diffusion of a protein on a fluctuating membrane
- Diffusion on Ruffled Membrane Surfaces
- Hybrid simulations of lateral diffusion in fluctuating membranes
- Curvature-coupling dependence of membrane protein diffusion coefficients
Cited by in corpus (30)
- Perspective: Dissipative Particle Dynamics
- Anomalous Dynamical Behavior of Freestanding Graphene Membranes
- Generalized Langevin equations for a driven tracer in dense soft colloids: construction and applications
- Dynamic simulations of multicomponent lipid membranes over long length and time scales
- Binding constants of membrane-anchored receptors and ligands: a general theory corroborated by Monte Carlo simulations
- Drag forces in classical fields
- Diffusing proteins on a fluctuating membrane: Analytical theory and simulations
- Correlated dynamics of inclusions in a supported membrane
- A perturbative path integral study of active and passive tracer diffusion in fluctuating fields
- Thermally activated vapor bubble nucleation: the Landau-Lifshitz/Van der Waals approach
- Diffusive motion of C60 on a graphene sheet
- Dynamics of membranes with immobile inclusions
- Low Mach Number Fluctuating Hydrodynamics of Diffusively Mixing Fluids
- Brownian motion meets Riemann curvature
- Drag forces on inclusions in classical fields with dissipative dynamics
- Multiscale approaches to protein-mediated interactions between membranes - Relating microscopic and macroscopic dynamics in radially growing adhesions
- Diffusion of active tracers in fluctuating fields
- Mobility Measurements Probe Conformational Changes in Membrane Proteins due to Tension
- Intrinsic and extrinsic measure for Brownian motion
- Diffusion of a particle quadratically coupled to a thermally fluctuating field
- A Variational Approach to Particles in Lipid Membranes
- Hydrodynamics of bilayer membranes with diffusing transmembrane proteins
- Tracer particle in a confined correlated medium: an adiabatic elimination method
- Statistical mechanics of a single active slider on a fluctuating interface
- Non-Gaussian fluctuations of a probe coupled to a Gaussian field
- Many-particle mobility and diffusion tensors for objects in viscous sheets
- Drift-Diffusion Dynamics and Phase Separation in Curved Cell Membranes and Dendritic Spines: Hybrid Discrete-Continuum Methods
- Hydrodynamic coupling between two fluid membranes
- Staggered Schemes for Fluctuating Hydrodynamics
- Homogenization of lateral diffusion on a random surface