Motility states of molecular motors engaged in a stochastic tug-of-war
arXiv:0812.2779 · doi:10.1007/s10955-008-9651-7
Abstract
Intracellular transport is mediated by molecular motors that pull cargos along cytoskeletal filaments. Many cargos move bidirectionally and are transported by two teams of motors which move into opposite directions along the filament. We have recently introduced a stochastic tug-of-war model for this situation. This model describes the motion of the cargo as a Markov process on a two-dimensional state space defined by the numbers of active plus and active minus motors. In spite of its simplicity, this tug-of-war model leads to a complex dependence of the cargo motility on the motor parameters. We present new numerical results for the dependence on the number of involved motors. In addition, we derive a simple and intuitive sharp maxima approximation, from which one obtains the cargo motility state from only four simple inequalities. This approach provides a fast and reliable method to determine the cargo motility for a given experimental system.
arXiv comment23 pages, latex, 12 figures, 1 table
References in corpus (5)
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Cited by in corpus (8)
- Fine-structured large deviations and the fluctuation theorem: Molecular motors and beyond
- Cargo transport by several motors
- Transport of organelles by elastically coupled motor proteins
- Dynein catch bond as a mediator of codependent bidirectional cellular transport
- Tug-of-war of molecular motors: the effects of uneven load sharing
- Simplification of the tug-of-war model for cellular transport in cells
- Properties of tug-of-war model for cargo transport by molecular motors
- Memory, Bias and Correlations in Bidirectional Transport of Molecular Motor-driven Cargoes