Random Time-Scale Invariant Diffusion and Transport Coefficients

Abstract

Single particle tracking of mRNA molecules and lipid granules in living cells shows that the time averaged mean squared displacement $\overline{{\delta }^2}$ of individual particles remains a random variable while indicating that the particle motion is subdiffusive. We investigate this type of ergodicity breaking within the continuous time random walk model and show that $\overline{{\delta }^2}$ differs from the corresponding ensemble average. In particular we derive the distribution for the fluctuations of the random variable $\overline{{\delta }^2}$. Similarly we quantify the response to a constant external field, revealing a generalization of the Einstein relation. Consequences for the interpretation of single molecule tracking data are discussed.

4 pages, 4 figures.Article accompanied by a PRL Viewpoint in Physics1, 8 (2008)

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