Traffic of cytoskeletal motors with disordered attachment rates
arXiv:0806.3845 · doi:10.1103/PhysRevE.81.031929
Abstract
Motivated by experimental results on the interplay between molecular motors and tau proteins, we extend lattice-based models of intracellular transport to include a second species of particle which locally influences the motor-filament attachment rate. We consider various exactly solvable limits of a stochastic multi-particle model before focusing on the low-motor-density regime. Here, an approximate treatment based on the random walk behaviour of single motors gives good quantitative agreement with simulation results for the tau-dependence of the motor current. Finally, we discuss the possible physiological implications of our results.
15 pages, 13 figures; revised version (to appear in Phys. Rev. E)
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Cited by in corpus (6)
- Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
- Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
- Phase diagram of two-lane driven diffusive systems
- A model for bidirectional traffic of cytoskeletal motors
- Totally asymmetric exclusion process with site-wise dynamic disorder
- Nonequilibrium steady states in coupled asymmetric and symmetric exclusion processes