1k citations
- University of CambridgeGB5 papers
- Addenbrooke's HospitalGB2 papers
- AstraZeneca (United Kingdom)GB2 papers
- Cambridge University Hospitals NHS Foundation TrustGB2 papers
- Genomics (United Kingdom)GB2 papers
- Imperial College LondonGB2 papers
- Medical University of ViennaAT2 papers
- University College LondonGB2 papers
- University of DundeeGB2 papers
- University of HelsinkiFI2 papers
- University of ManchesterGB2 papers
- Boehringer Ingelheim (Germany)DE1 paper
5 papers
Introducing precision-weighted bias as a performance measure to inform the inclusion of adaptive designs in meta-analysis
Martin Law, David S. Robertson, Sofia S. Villar +4
We propose a novel, intuitive measure of statistical performance: precision-weighted bias. Precision-weighted bias is defined as the unconditional bias of an estimator weighted by…
Implementing Response-Adaptive Randomisation in Stratified Rare-disease Trials: Design Challenges and Practical Solutions
Rajenki Das, Nina Deliu, Mark Toshner +1
Although response-adaptive randomisation (RAR) has gained substantial attention in the literature, it still has limited use in clinical trials. Amongst other reasons, the implement…
Navigating the challenges in creating complex data systems: a development philosophy
Sören Dittmer, Michael Roberts, Julian Gilbey +6
In this perspective, we argue that despite the democratization of powerful tools for data science and machine learning over the last decade, developing the code for a trustworthy a…
Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans
Michael Roberts, Derek Driggs, Matthew Thorpe +13
Machine learning methods offer great promise for fast and accurate detection and prognostication of COVID-19 from standard-of-care chest radiographs (CXR) and computed tomography (…
On disc protoplanet interactions in a non-barotropic disc with thermal diffusion
S. -J. Paardekooper, J. C. B. Papaloizou
We study the disc planet interactions of low-mass protoplanets embedded in a circumstellar disc. We extend the standard theory of planet migration from the usual locally isothermal…