2 papers
stat.ME2022
Point estimation for adaptive trial designs II: practical considerations and guidance
David S. Robertson, Babak Choodari-Oskooei, Munya Dimairo +3
In adaptive clinical trials, the conventional end-of-trial point estimate of a treatment effect is prone to bias, that is, a systematic tendency to deviate from its true value. As…
stat.ME2019
Adding new experimental arms to randomised clinical trials: impact on error rates
Babak Choodari-Oskooei, Daniel J Bratton, Melissa R Gannon +3
Background: Experimental treatments pass through various stages of development. If a treatment passes through early phase experiments, the investigators may want to assess it in a…