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20102020
most citedPredicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

282 citations

Showing q-bio.PEShow all

8 papers · 1 filter

q-bio.PE2020★ 110 cited

From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics

Susanna Manrubia, José A. Cuesta, Jacobo Aguirre +15

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to t…

q-bio.PE2016★ 18 cited

Detecting the Collapse of Cooperation in Evolving Networks

Matteo Cavaliere, Guoli Yang, Vincent Danos +1

The sustainability of structured biological, social, economic and ecological communities are often determined by the outcome of social conflicts between cooperative and selfish ind…

q-bio.PE2014★ 144 cited

Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy

Feng Fu, Martin A. Nowak, Sebastian Bonhoeffer

Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity…

q-bio.PE2014★ 282 cited

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

Alison L. Hill, Daniel I. S. Rosenbloom, Feng Fu +2

Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-rever…

q-bio.PE2013★ 131 cited

Evolutionary Game Dynamics in Populations with Heterogeneous Structures

Wes Maciejewski, Feng Fu, Christoph Hauert

Evolutionary graph theory is a well established framework for modelling the evolution of social behaviours in structured populations. An emerging consensus in this field is that gr…

q-bio.PE2013★ 4 cited

Macro-evolutionary models and coalescent point processes: The shape and probability of reconstructed phylogenies

Amaury Lambert, Tanja Stadler

Forward-time models of diversification (i.e., speciation and extinction) produce phylogenetic trees that grow "vertically" as time goes by. Pruning the extinct lineages out of such…

q-bio.PE2013

Phylogenetic analysis accounting for age-dependent death and sampling with applications to epidemics

Amaury Lambert, Helen K. Alexander, Tanja Stadler

The reconstruction of phylogenetic trees based on viral genetic sequence data sequentially sampled from an epidemic provides estimates of the past transmission dynamics, by fitting…

q-bio.PE2013★ 70 cited

Can high risk fungicides be used in mixtures without selecting for fungicide resistance?

Alexey Mikaberidze, Bruce A. McDonald, Sebastian Bonhoeffer

Fungicide mixtures produced by the agrochemical industry often contain low-risk fungicides, to which fungal pathogens are fully sensitive, together with high-risk fungicides known…