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4 papers · 1 filter
Estimating the Optimal Linear Combination of Biomarkers using Spherically Constrained Optimization
Priyam Das, Debsurya De, Raju Maiti +5
In the context of a binary classification problem, the optimal linear combination of continuous predictors can be estimated by maximizing an empirical estimate of the area under th…
A deep learning model for segmentation of geographic atrophy to study its long-term natural history
Bart Liefers, Johanna M. Colijn, Cristina González-Gonzalo +6
Purpose: To develop and validate a deep learning model for automatic segmentation of geographic atrophy (GA) in color fundus images (CFIs) and its application to study growth rate…
A distribution-free smoothed combination method of biomarkers to improve diagnostic accuracy in multi-category classification
Raju Maiti, Jialiang Li, Priyam Das +3
Results from multiple diagnostic tests are usually combined to improve the overall diagnostic accuracy. For binary classification, maximization of the empirical estimate of the are…
SMARTp: A SMART design for non-surgical treatments of chronic periodontitis with spatially-referenced and non-randomly missing skewed outcomes
Jing Xu, Dipankar Bandyopadhyay, Sedigheh Mirzaei +2
This paper proposes dynamic treatment regimes for choosing individualized effective treatment strategies of chronic periodontal disease. R codes for implementing the proposed sampl…