331 citations
- Centre National de la Recherche ScientifiqueFR73 papers
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6 papers · 1 filter
Snare machinery is optimized for ultrafast fusion
Fabio Manca, Frederic Pincet, Lev Truskinovsky +3
SNARE proteins zipper to form SNAREpins that power vesicle fusion with target membranes in a variety of biological processes. A single SNAREpin takes about 1 second to fuse two bil…
Physics of muscle contraction
Matthieu Caruel, Lev Truskinovsky
In this paper we report, clarify and broaden various recent efforts to complement the chemistry-centered models of force generation in muscles by mechanics-centered models. The phy…
Bi-stability resistant to fluctuations
Matthieu Caruel, Lev Truskinovsky
We study a simple micro-mechanical device that does not lose its snap-through behavior in an environment dominated by fluctuations. The main idea is to have several degrees of free…
Statistical mechanics of the Huxley-Simmons model
M Caruel, L Truskinovsky
The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)] provides a paradigmatic description of mechanically induced collective…
Paramagnetic response of muscle-type systems
Matthieu Caruel, Lev Truskinovsky
We provide a prototypical description of mechanically-induced collective conformational change (folding), relevant in a variety of biological contexts from muscle contraction to ha…
Mechanics of collective unfolding
M Caruel, J. -M Allain, L Truskinovsky
Mechanically induced unfolding of passive crosslinkers is a fundamental biological phenomenon encountered across the scales from individual macro-molecules to cytoskeletal actin ne…