145 citations
5 papers
A 3D Pancreatic Cancer Model with Integrated Optical Sensors for Noninvasive Metabolism Monitoring and Drug Screening
Anna Chiara Siciliano, Stefania Forciniti, Valentina Onesto +6
A distinct feature of pancreatic ductal adenocarcinoma (PDAC) is a prominent tumor microenvironment (TME) with remarkable cellular and spatial heterogeneity that meaningfully impac…
A synergic approach to enhance long term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids
Marta Cavo, Donatella Delle Cave, Eliana D'Amone +3
Tumour spheroids have the potential to be used as preclinical chemosensitivity assays. However, the production of three dimensional (3D) tumour spheroids remains challenging as not…
Thermodynamic pathways to genome spatial organization in the cell nucleus
Mario Nicodemi, Antonella Prisco
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity…
A thermodynamic switch for chromosome colocalization
M. Nicodemi, B. Panning, A. Prisco
A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on a thermodynamic ground, how the distance between two homologous DN…
A Symmetry Breaking Model for X Chromosome Inactivation
M. Nicodemi, A. Prisco
In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-in…