97 citations · 370 across the 11 of their papers we have counts for
11 papers
A 3D Pancreatic Cancer Model with Integrated Optical Sensors for Noninvasive Metabolism Monitoring and Drug Screening
Anna Chiara Siciliano, Stefania Forciniti, Valentina Onesto +6
A distinct feature of pancreatic ductal adenocarcinoma (PDAC) is a prominent tumor microenvironment (TME) with remarkable cellular and spatial heterogeneity that meaningfully impac…
Highly Sensitive Ratiometric Fluorescent Fiber Matrixes for Oxygen Sensing with Micrometer-Spatial Resolution
Giuliana Grasso, Valentina Onesto, Stefania Forciniti +8
Oxygen (O2)-sensing matrices are promising tools for the live monitoring of extracellular O2 consumption levels in long-term cell cultures. In this study, ratiometric O2-sensing me…
Metabolic coordination and phase transitions in spatially distributed multi-cellular systems
Krishnadev Narayanankutty, José Antonio Pereiro-Morejon, Arián Ferrero-Fernández +7
During overflow metabolism, cells excrete glycolytic byproducts when growing under aerobic conditions in a seemingly wasteful fashion. While potentially advantageous for microbes w…
A pH Sensor Scaffold for Mapping Spatiotemporal Gradients in Three Dimensional In Vitro Tumour Models
Riccardo Rizzo, Valentina Onesto, Stefania Forciniti +6
The detection of extracellular pH at single cell resolution is challenging and requires advanced sensibility. Sensing pH at a high spatial and temporal resolution might provide cru…
Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications
Giuliana Grasso, Francesco Colella, Stefania Forciniti +7
The tumor microenvironment (TME) features distinct hallmarks, including acidosis, hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial targe…
NIR ICG-Enhanced Fluorescence: A Quantitative Evaluation of Bowel Microperfusion and Its Relation to Central Perfusion in Colorectal Surgery
N. Depalma, S. D Ugo, F. Manoochehri +10
Background: To date, no standardized protocols nor a quantitative assessment of the near-infrared fluorescence angiography with indocyanine green (NIR-ICG) are available. The aim o…
Co-loading of doxorubicin and iron oxide nanocubes in polycaprolactone fibers for combining Magneto-Thermal and chemotherapeutic effects on cancer cells
Francesca Serio, Niccolò Silvestri, Sahitya Kumar Avugadda +8
Among the strategies to fight cancer, multi-therapeutic approaches are considered as a wise choice to put in place multiple weapons to suppress tumors. In this work, to combine che…
Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models
Matteo Turetta, Fabio Del Ben, Giulia Brisotto +7
In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to micro…
Towards the development of human immune-system-on-a-chip platforms
Alessandro Polini, Loretta L. del Mercato, Adriano Barra +3
Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected…
Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends
S. Prasad, A. Chandra, M. Cavo +8
The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are…
Ratiometric Organic Fibers for Localized and Reversible Ion Sensing with Micrometer-Scale Spatial Resolution
Loretta L. del Mercato, Maria Moffa, Rosaria Rinaldi +1
A fundamental issue in biomedical and environmental sciences is the development of sensitive and robust sensors able to probe the analyte of interest, under physiological and patho…