21 citations
2 papers
math.AP2002
Control of Spatially Heterogeneous and Time-Varying Cellular Reaction Networks: A New Summation Law
Mark A. Peletier, Hans V. Westerhoff, Boris N. Kholodenko
A hallmark of a plethora of intracellular signaling pathways is the spatial separation of activation and deactivation processes that potentially results in precipitous gradients of…
physics.bio-ph2002★ 21 cited
Determination of Functional Network Structure from Local Parameter Dependence Data
Boris N. Kholodenko, Eduardo D. Sontag
In many applications, such as those arising from the field of cellular networks, it is often desired to determine the interaction (graph) structure of a set of differential equatio…