most citedInvestigation of particle dynamics and classification mechanism in a spiral jet mill through computational fluid dynamics and discrete element methods

42 citations

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physics.app-ph2025★ 39 cited

Coupled CFD-DEM model for dry powder inhalers simulation: validation and sensitivity analysis for the main model parameters

Raffaele Ponzini, Roberto Da Vià, Simone Bnà +2

The use of computational techniques in the design of dry powder inhalers (DPI), as well as in unravelling the complex mechanisms of drug aerosolization, has increased significantly…

physics.app-ph2025★ 19 cited

Quantifying the loading capacity of a carrier-based DPI formulation and its dependence on the blending process

Andrea Benassi, Ilaria Perazzi, Roberto Bosi +2

Non-segregating ordered powder mixtures constituted by a coarse carrier fraction and finer components are at the basis of dry powders for inhalation pharmaceuticas. The estimation…