42 citations · 97 across the 5 of their papers we have counts for
7 papers
Coupled CFD-DEM model for dry powder inhalers simulation: validation and sensitivity analysis for the main model parameters
Raffaele Ponzini, Roberto Da Vià, Simone Bnà +2
The use of computational techniques in the design of dry powder inhalers (DPI), as well as in unravelling the complex mechanisms of drug aerosolization, has increased significantly…
Investigation of particle dynamics and classification mechanism in a spiral jet mill through computational fluid dynamics and discrete element methods
Simone Bnà, Raffaele Ponzini, Mirko Cestari +3
Predicting the outcome of jet-milling based on the knowledge of process parameters and starting material properties is a task still far from being accomplished. Given the technical…
A shear cell study on oral and inhalation grade lactose powders
Giulio Cavalli, Roberto Bosi, Alessandro Ghiretti +3
Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation purposes, spanning a wide range of particle si…
CFD simulation of a Rushton turbine stirred-tank using open-source software with critical evaluation of MRF-based rotation modeling
Alfred Reid, Riccardo Rossi, Ciro Cottini +1
A critical evaluation of the impact of the Multiple Reference Frame (MRF) technique on steady RANS simulations of a Rushton turbine stirred-tanks is presented. The analysis, based…
A computational fluid dynamics model for the simulation of flashboiling flow inside pressurized metered dose inhalers
Riccardo Rossi, Ciro Cottini, Andrea Benassi
In this work we present, for the first time, a computational fluid dynamics tool for the simulation of the metered discharge in a pressurized metered dose inhaler. The model, based…
Direct numerical simulations of inhalation in a 23-generation lung model
Marco Atzori, Emanuele Gallorini, Ciro Cottini +2
The air flows in the proximal and distal portions of the human lungs are interconnected: the lower Reynolds number in the deeper generations causes a progressive flow regularizatio…
The breakdown of superlubricity by driving-induced commensurate dislocations
Andrea Benassi, Ming Ma, Michael Urbakh +1
In the framework of a Frenkel-Kontorova-like model, we address the robustness of the superlubricity phenomenon in an edge-driven system at large scales, highlighting the dynamical…