42 citations
7 papers
Coupled CFD-DEM model for dry powder inhalers simulation: validation and sensitivity analysis for the main model parameters
Raffaele Ponzini, Roberto Da Vià, Simone Bnà +2
The use of computational techniques in the design of dry powder inhalers (DPI), as well as in unravelling the complex mechanisms of drug aerosolization, has increased significantly…
Investigation of particle dynamics and classification mechanism in a spiral jet mill through computational fluid dynamics and discrete element methods
Simone Bnà, Raffaele Ponzini, Mirko Cestari +3
Predicting the outcome of jet-milling based on the knowledge of process parameters and starting material properties is a task still far from being accomplished. Given the technical…
A shear cell study on oral and inhalation grade lactose powders
Giulio Cavalli, Roberto Bosi, Alessandro Ghiretti +3
Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation purposes, spanning a wide range of particle si…
Quantifying the loading capacity of a carrier-based DPI formulation and its dependence on the blending process
Andrea Benassi, Ilaria Perazzi, Roberto Bosi +2
Non-segregating ordered powder mixtures constituted by a coarse carrier fraction and finer components are at the basis of dry powders for inhalation pharmaceuticas. The estimation…
CFD simulation of a Rushton turbine stirred-tank using open-source software with critical evaluation of MRF-based rotation modeling
Alfred Reid, Riccardo Rossi, Ciro Cottini +1
A critical evaluation of the impact of the Multiple Reference Frame (MRF) technique on steady RANS simulations of a Rushton turbine stirred-tanks is presented. The analysis, based…
Mechanical characterization of pharmaceutical powders and correlation with their behavior during grinding
Laura Baraldi, Davide De Angelis, Roberto Bosi +4
Controlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques…