169 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- German Cancer Research CenterDE13 papers
- Heidelberg UniversityDE12 papers
- Technische Universität DresdenDE4 papers
- University Hospital HeidelbergDE4 papers
- GSI Helmholtz Centre for Heavy Ion ResearchDE3 papers
- Helmholtz-Zentrum Dresden-RossendorfDE3 papers
- Karlsruhe Institute of TechnologyDE3 papers
- Ludwig-Maximilians-Universität MünchenDE3 papers
- National Center for Tumor DiseasesDE3 papers
- OncoRayDE3 papers
- University Hospital Carl Gustav CarusDE3 papers
- Deutsches Konsortium für Translationale KrebsforschungDE2 papers
19 papers
Clinical beam test of inter- and intra-fraction relative range monitoring in carbon ion radiotherapy
Devin Hymers, Sebastian Schroeder, Olga Bertini +5
Interaction Vertex Imaging (IVI) is used for range monitoring (RM) in carbon ion radiotherapy. The purpose of RM is to measure the Bragg peak (BP) position for each contributing be…
Direct optimization of the probability of lesion origin in proton treatment planning for low-grade glioma patients
Tim Ortkamp, Habiba Sallem, Semi Harrabi +4
In proton therapy of low-grade glioma (LGG) patients, contrast-enhancing brain lesions (CEBLs) on magnetic resonance imaging are considered predictive of late radiation-induced les…
An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti +4
Nanodosimetry relates Ionization Detail (ID) and ionization parameters (Ip) to biological endpoints relevant for charged-particle radiotherapy. This supports a more physics-based m…
Helium Range Viability for Online Range Probing in Mixed Carbon-Helium Beams
Jennifer J. Hardt, Alexander A. Pryanichnikov, Oliver Jäkel +2
Background: Recently, mixed carbon-helium beams were proposed for range verification in carbon ion therapy: Helium, with three times the range of carbon, serves as an on-line range…
Knock Out Slow Extraction Using Betatron Sidebands at High Harmonics
Philipp Niedermayer, Rahul Singh, Eike Feldmeier +2
Radio frequency knock out resonant slow extraction is a standard method for extracting stored particle beams from synchrotrons by transverse excitation. Excitation signals comprisi…
SynthRAD2025 Grand Challenge dataset: generating synthetic CTs for radiotherapy
Adrian Thummerer, Erik van der Bijl, Arthur Jr Galapon +16
Medical imaging is essential in modern radiotherapy, supporting diagnosis, treatment planning, and monitoring. Synthetic imaging, particularly synthetic computed tomography (sCT),…
Scenario-free robust optimization algorithm for IMRT and IMPT treatment planning
Remo Cristoforetti, Jennifer Josephine Hardt, Niklas Wahl
Robust treatment planning algorithms for Intensity Modulated Proton Therapy (IMPT) and Intensity Modulated Radiation Therapy (IMRT) allow for uncertainty reduction in the delivered…
First experimental test of a coded-mask gamma camera for proton therapy monitoring
Magdalena Kołodziej, Stephan Brons, Mikołaj Dubiel +15
Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the…
Interpretation of the horizontal beam response near the third integer resonance
E. C. Cortés García, P. Niedermayer, R. Singh +5
The beam response to an external periodic excitation delivers relevant information about the optics, tune distribution and stability of a circulating beam in a storage ring. In thi…
An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters
Ruirui Liu, Serdar Charyyev, Niklas Wahl +10
Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet t…
Multivariate error modeling and uncertainty quantification using importance (re-)weighting for Monte Carlo simulations in particle transport
Pia Stammer, Lucas Burigo, Oliver Jäkel +2
Fast and accurate predictions of uncertainties in the computed dose are crucial for the determination of robust treatment plans in radiation therapy. This requires the solution of…
Efficient uncertainty quantification for Monte Carlo dose calculations using importance (re-)weighting
Pia Stammer, Lucas Burigo, Oliver Jäkel +2
The high precision and conformity of intensity-modulated particle therapy (IMPT) comes at the cost of susceptibility to treatment uncertainties in particle range and patient set-up…
Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions
Jeannette Jansen, Jan Knoll, Elke Beyreuther +6
Purpose: To investigate experimentally, if FLASH irradiation depletes oxygen within water for different radiation types such as photons, protons and carbon ions. Methods: This stud…
Analytical probabilistic modeling of dose-volume histograms
Niklas Wahl, Philipp Hennig, Hans-Peter Wieser +1
Radiotherapy is sensitive to executional and preparational uncertainties that propagate to uncertainty in dose and plan quality indicators like dose-volume histograms (DVHs). Curre…
Impact of new ICRU90 key data on stopping-power ratios and beam quality correction factors for carbon ion beams
Lucas Burigo, Steffen Greilich
The recent update of dosimetric key data by the `International Commission on Radiation Units and Measurements' impacts the computation of beam quality correction factors via…
MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI
Charlotte Debus, Ralf Floca, Michael Ingrisch +4
Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in DCE MRI/CT, ADC calcu…
Experimental verification of stopping-power prediction from single- and dual-energy computed tomography in biological tissues
Christian Möhler, Tom Russ, Patrick Wohlfahrt +4
An experimental setup for consecutive measurement of ion and x-ray absorption in tissue or other materials is introduced. With this setup using a 3D-printed sample container, the r…
Range prediction for tissue mixtures based on dual-energy CT
Christian Möhler, Patrick Wohlfahrt, Christian Richter +1
The use of dual-energy CT (DECT) potentially decreases range uncertainties in proton and ion therapy treatment planning via determination of the involved physical target quantities…
Methodological accuracy of image-based electron-density assessment using dual-energy computed tomography
Christian Möhler, Patrick Wohlfahrt, Christian Richter +1
Purpose: Electron density is the most important tissue property influencing photon and ion dose distributions in radiotherapy patients. Dual-energy computed tomography (DECT) enabl…