most citedBayesian dose-regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics

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stat.ME2020★ 1 cited

Bayesian dose-regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics

Emma Gerard, Sarah Zohar, Hoai-Thu Thai +3

Phase I dose-finding trials in oncology seek to find the maximum tolerated dose (MTD) of a drug under a specific schedule. Evaluating drug-schedules aims at improving treatment saf…